Momordica charantia L. is a herbaceous climbing plant in the genus Momordica of family Cucurbitaceae. It is to study the chemical constituents of Momordica charantia L. leaves and establish the method for determination of their total saponin content. Momordica charantia L. leaves are isolated and purified by silica gel and Sephadex LH-20 column chromatographies, and the resulting compounds are ...

Focusing on a functional component of Momordica charantia, saponin, we investigated its effects on serum glucose and neutral fat levels. Saponin was extracted as a butanol-soluble fraction (saponin fraction) from hot blast-dried Momordica charantia powder. The disaccharidase-inhibitory activity and the pancreatic lipase-inhibitory activity of the saponin fraction were measured, and in vivo suga...

1. Duke AJ. Handbook of Medicinal Herbs, Second edition. Boca Raton: CRC Press Inc; 1989: p. 315-6. 2. Cunnick J, Takemoto D. Bitter melon (Mormordica charantia). J Nat Med 1993;4:16-21. 3. Chandrasekar B, Mukherjee B, Mukherjee SK. Blood sugar lowering potentiality of selected Cucurbitaceae plants of Indian origin. Indian J Med Res 1989;90:300–5. 4. Srivastava Y, Venkatakrishna-Bhatt H, Verma ...

In an attempt to screen the hypogly-caemic activity of Momordica charantia fruit (Karela) the proximate analysis, alkaloidal tests and its effects on blood glucose levels of normal male albino rabbits were determined. Whole dried and powdered Momordica charantia fruit was used for this purpose and blood glucose was determined by O-toluidine method at various time intervals. The proximate analys...

Background: Momordica charantia is used in China for its jianghuo (heat-clearing and detoxifying) effects. The concept of shanghuo (the antonym of jianghuo, excessive internal heat) in traditional Chinese medicine is considered a type of stress response of the body. The stress process involves internal organs, especially the liver. Objective: We hypothesized that Momordica charantia water extra...

Background: Considering the increasing resistance of bacteria to antibiotics and the presence of antibacterial agents in plantsObjectives: the aim of this study was the antimicrobial and antibiofilm activity of Tecomella undulata and Momordica charantia ethanol and aceton leaf extract on antibiotic resistance Acinetobacter baumannii.Methods: The leaves of Tecomella undulata and Momo...

Renal function tests (serum creatinine, urea and uric acid), were performed in acetaminophen-intoxicated rabbits during hepatoprotective and hepatocurative treatment with Momordica charantia fruit extract. In hepatocurative group, the M. charantia treatment was preceded by acetaminophen intoxication, whereas, in hepatoprotective group, the acetaminophen intoxication was preceded by M. charantia...

The aim of the present study was to evaluate the Analgesic & anti inflammatory activities of the Momordica charantia extract. Momordica chirantia (MC) is a herbal medicine traditionally applied to treat so many diseases and disorders. In the evaluation of analgesic activity the model used was Eddy’s hot plate method in which the animals treated with Momordica charantia and standard Pentazocin h...

Momordica charantia Linn. (karela) is an herbal climber grown in tropical and subtropical regions, belonging to the Cucurbitaceae family. Momordica charantia (Karela) have provided many remedies for various diseases from ancient days to now a day. It has been used in various Asian traditional medicines for the treatment of cholera, bronchitis, anemia, blood diseases, ulcer, diarrhea, dysentery,...

Background/Objective We investigate the effect of antidiabetic Momordica charantia fruit juice on T cells' differentiation, through plasmatic cytokine quantification in type 1 diabetic rats (T1D). Methods Male Wistar rats were rendered diabetic by the injection of five low doses of streptozotocin. Then, animals were treated with Momordica charantia fruit juice for 28 consecutive days. Plasmat...